Epinephrine - As a result of opportunity for promethazine to reverse epinephrine’s vasopressor impact, epinephrine should NOT be utilized to treat hypotension associated with promethazine overdose.
It is vital that Promethazine HCl Oral Solution is measured having an correct measuring device (see Safeguards-Info for Clients). A family teaspoon is just not an exact measuring system and could lead on to overdosage, especially when 50 % a teaspoon is always to be measured.
patients that are allergic to promethazine, any from the components in promethazine, or to other phenothiazines
The diagnostic analysis of clients using this syndrome is intricate. In arriving in a prognosis, it is crucial to detect conditions where the scientific presentation features equally serious clinical ailment (e.
Stimulation could possibly be obvious, specifically in youngsters and geriatric clients. Convulsions may perhaps seldom arise. A paradoxical-style response continues to be documented in young children acquiring one doses of seventy five mg to a hundred twenty five mg orally, characterised by hyperexcitability and nightmares.
Codeine is thought to be significantly excreted from the kidney, and the chance of adverse reactions to this drug might be larger in individuals with impaired renal purpose.
Codeine: A analyze in rats and rabbits described no teratogenic effect of codeine administered over the duration of organogenesis in doses starting from five to one hundred twenty mg/kg. During the rat, doses in the 120-mg/kg amount, inside the toxic assortment to the Grownup animal, were being connected with a rise in embryo resorption at enough time of implantation.
For the reason that these reactions might be claimed voluntarily from the population of unsure dimension, It is far from often doable to reliably estimate their frequency or establish a causal romance to drug publicity.
Remedy of Overdose Remedy of overdosage is driven by the overall clinical presentation, and is made up of discontinuation of Promethazine HCl and Codeine Phosphate Oral Remedy together with establishment of ideal therapy. Give Main notice to the reestablishment of enough respiratory Trade as a result of provision of the patent and protected airway and the institution of assisted or controlled ventilation.
two) Position the combination within a sealable bag, vacant can, or other container to circumvent the drug from leaking or breaking outside of a rubbish bag, or to dispose of in accordance with nearby state rules and/or restrictions.
The outcome of promethazine and/or codeine on later progress and advancement on the new child is mysterious.
Promethazine shouldn't be used in pediatric people a lot less than 2 years of age due to likely for fatal respiratory melancholy.
Good evaluation from the individual, right prescribing practices, periodic re-evaluation of therapy, and correct dispensing and storage are acceptable measures that enable to Restrict abuse of opioid drugs.
Area the combination in a very container for instance a sealed plastic bag and toss it absent during the home trash. You may also comply with your condition or here regional pointers on how to safely toss absent Promethazine Hydrochloride and Codeine Phosphate Oral Option.